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The aim of the study is to compare concentrations of cadmium and nickel that induce negative effects on survival and life cycle parameters of active and resting stages of cladoceran Moina macrocopa. In acute and chronic tests with active animals we determined standard toxicological parameters: half lethal concentration (LC50) when 50 % mortality of tested animals is observed and effective concentration (EC50) when 50 % reduction of the net reproductive rate of females of Moina macrocopa is detected. LC50 for cadmium in 48-hours test was equal to 0.18 mg/l; for nickel - 5.59 mg/l. EC50 for cadmium was equal to 0.005 mg/l, for nickel - 0.323 mg/l. It was demonstrated that long-term (30-40 days) exposure of resting eggs of M. macrocopa to the effect of solutes of cadmium and nickel in the wide range of concentrations (from background to the 60-70 g/l) did not affect the survival of resting eggs and life cycle parameters (specific rate of juvenile growth, number of hatched clutches, net reproductive rate) of hatchlings from exposed eggs. Thus, resting eggs of M. macrocopa can tolerate without negative survival effects concentrations of toxicants that far exceed the concentrations that are toxic for active animals, which confirm high resistance of resting eggs to the effect of heavy metals.