Details

Autor(en) / Beteiligte

• Yurova, K. A.
• Khaziakhmatova, O. G.
• Dunets, N. A.
• Todosenko, N. M.
• Shupletsova, V. V.
• Litvinova, L. S.

Titel

Effect of cytokines (IL-2, IL-7, and IL-15) having common γ-chain of receptors on differentiation and maturation of CD4+/CD8+ T-cells in a CD45RA T-lymphocyte population in vitro

Ist Teil von

• Cell and tissue biology, 2017-09, Vol.11 (5), p.356-362

Ort / Verlag

Moscow: Pleiades Publishing

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The effect of cytokines (IL-2, IL-7, and IL-15) having a common γ-chain of receptors on the maturation and differentiation of CD3 + CD45RA + CD4 + /CD8 + lymphocytes in homeostatic cultivation model in vitro was analyzed. It was found that the maximum IL-2 concentration in the helper CD45RA + -T-cell population mediates an increase in the number of CD45RA + CD4 + T lymphocytes with the phenotype of mature and immature terminally differentiated TEMRA T cells. IL-15 leads to the production of lymphocytes with CD27 – CD62L + phenotype (presumably, TEMRA, in which the CD62L expression persists). In the CD45RA + CD8 + T lymphocyte populations, the studied cytokines (IL-2, IL-7, and IL-15) initiate the production of mature TEMRA (E) T lymphocytes and memory T cells with the CD45RA − CD27 + CD62L + central phenotype (TCM).