Details

Autor(en) / Beteiligte

• Kushwaha, Archana
• Jaiswal, Jayanti
• Singh, Priya
• Rathore, Neha
• Dhruw, Jai Prakash
• Sahu, Ishu
• Singh, Chhaya
• Sahu, Krinsha Kumar
• Agrawal, Mukta
• Tripathi, D. K.
• Ajazuddin
• Alexander, Amit

Titel

An exhaustive review based on the formulation and evaluation methods behind the development of transdermal drug delivery systems

Ist Teil von

• Research journal of pharmacy and technology, 2017-05, Vol.10 (5), p.1531

Ort / Verlag

Raipur: A&V Publications

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug diclofenac with different ratios of hydrophilic (hydroxyl propyl cellulose) and hydrophobic (ethyl cellulose) polymeric systems polymeric systems by the solvent evaporation technique and by using Glycerol as plasticizer .Different concentrations of oleic acid and isopropyl myristate were used to enhance the transdermal permeation of Diclofenac. POLYMER MATRIX The Polymer controls the release of the drug from the device. a) Natural Polymers: Cellulose derivatives, Gelatin, Shellac, Waxes, Proteins, Gums and their derivatives, Natural rubber, Starch etc. b) Synthetic Elastomers: Polybutadieine, Hydrin rubber, Polysiloxane, Silicone rubber, Nitrile, Acrylonitrile, Butyl rubber, Styrenebutadieine rubber, Neoprene etc. c) Synthetic Polymers: Polyvinyl alcohol, Polyvinyl chloride, Polyethylene, Polypropylene, Polyacrylate, Polyamide, Polyurea, Polyvinylpyrrolidone, Polymethylmethacrylate, Epoxy etc. Interaction studies are taken out by Thermal analysis, Fourier transform infrared spectroscopy (FTIR), ultra violet (UV) and chromatographic techniques by comparing their physicochemical properties like assay, melting point, wave numbers, and absorption maxima. [32-35] In vitro skin permeation studies An in vitro permeation study can be carried out by using diffusion cell on thick abdominal skin of male Wistar rats weighing 200 to 250 g. Hair from the abdominal region is removed carefully by using an electric clipper; the dermal side of the skin was thoroughly cleaned with distilled water to remove any adhering tissues or blood vessels, equilibrated for an hour in dissolution medium or phosphate buffer pH 7.4 before starting the experiment, and was placed on a magnetic stirrer with a small magnetic needle for uniform distribution of the diffusant.