Details

Autor(en) / Beteiligte

• Mori, Akio
• Ogawa, Koji
• Someya, Koichiro
• Kunori, Yuichi
• Nagakubo, Daisuke
• Yoshie, Osamu
• Kitamura, Fujiko
• Hiroi, Takachika
• Kaminuma, Osamu

Titel

Selective suppression of T[sub]h2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists

Ist Teil von

• International immunology, 2007-08, Vol.19 (8), p.913

Ort / Verlag

Oxford: Oxford Publishing Limited (England)

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The effects of selective CC chemokine receptor (CCR)-3 antagonists on antigen-induced leukocyte accumulation in the lungs of mice adoptively transferred with in vitro -differentiated Th 1 and Th 2 were investigated. Inhalation of antigen by mice injected with Th 1 and Th 2 initiated the migration of T cells themselves into the lungs. Subsequently, neutrophils massively accumulated in Th 1-transferred mice, whereas eosinophil infiltration was specifically induced by Th 2. CCR3 antagonists, SB-297006 and/or SB-328437, suppressed antigen-induced accumulation of Th 2 as well as eosinophils in the lungs, whereas they failed to affect Th 1-mediated airway inflammation. Not only Th 2 and eosinophil infiltration but also cellular mobilization in Th 1-transferred mice was attenuated by an anti-CC chemokine ligand-11 antibody. CCR3 antagonists reduced chemokine production in the lungs of mice transferred with Th 2 but not Th 1, suggesting that down-regulation of chemokine synthesis is involved in the selective inhibition of Th 2-mediated eosinophil infiltration by CCR3 antagonists.