Details

Autor(en) / Beteiligte

• Chandrakar, Ashok
• Sahu, Bishesar
• Sahu, Homendra
• Dewangan, Jagdish
• Kumar, Navin
• Singh, Rajat
• Gupta, Rohit
• Kumar, Devesh
• Sahu, Bhishm
• Dewangan, Kuldeep
• Kaushal, Rishi
• Agrawal, Mukta
• Tripathi, D. K.
• Ajazuddin
• Alexander, Amit

Titel

Review on the formulation considerations needed to produce a stable Self micro Emulsifying Drug Delivery System (SMEDDS)

Ist Teil von

• Research journal of pharmacy and technology, 2017-05, Vol.10 (5), p.1563

Ort / Verlag

Raipur: A&V Publications

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [1]Recently, synthesized drug that are being discovered are lipophilic in nature and have poor aqueous solubility, thereby posing problems in their formulation into delivery systems. Because of their low aqueous solubility and low permeability, dissolution and/or release rate from the delivery system forms the rate-limiting step in their absorption and systemic availability. The drawbacks of this system include chemical instabilities of drugs and high surfactant concentrations in formulations (approximately 3060%) which irritate GIT. 6. [...]volatile co solvents in the conventional self-microemulsifying formulations are known to migrate into the shells of soft or hard gelatin capsules, resulting in the precipitation of the lipophilic drugs. 7. Solubilization in SMEDDS Owing to their frequently high content oil, as well as of surfactant, SMEDDS are usually efficient solubilizers of substances of a wide range of lipophilicity. [...]the solubilizing capacity of a w/o micro emulsion for water soluble drugs is typically higher than that of an o/w micro emulsion, while the reverse is true for oil soluble drugs. Furthermore, the solubilization depends on the SMEDDS composition1-29-1. 4.Sustain release from SMEDDS Due to the wide range of structures occurring in them, SMEDDS display a rich behavior regarding the release of solubilized material. [...]in case of O/W micro emulsion, hydrophobic drugs solubilized mainly in the oil droplets, experience hindered diffusion and are therefore released rather slowly (depending on the oil/water partitioning of the substance).