Details

Autor(en) / Beteiligte

• Dickschat, Jeroen S.

Titel

Modern Aspects of Isotopic Labellings in Terpene Biosynthesis

Ist Teil von

• European journal of organic chemistry, 2017-09, Vol.2017 (33), p.4872-4882

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• In this review article recent isotopic labelling experiments are presented that served in the elucidation of the complex mechanisms of terpene biosynthesis. The article is structured by first presenting the recent advances in the biosynthesis of terpene monomers, followed by sections on monoterpenes, sesquiterpenes and diterpenes. This overview covers a personal selection of eminent examples from the accumulated literature since 2010. This review summarises the results of recent mechanistic investigations on enzymes involved in the biosynthesis of terpene precursors and on terpene cyclases by isotopic labelling experiments. The accumulated knowledge from these experiments is discussed against the background of insights obtained by quantum chemical calculations.