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Pseudogenization of the Humanin gene is common in the mitochondrial DNA of many vertebrates
Ist Teil von
Dōngwùxué yánjiū, 2017-07, Vol.38 (4), p.198
Ort / Verlag
China: Kunming Institute of Zoology, The Chinese Academy of Sciences
Erscheinungsjahr
2017
Quelle
MEDLINE
Beschreibungen/Notizen
In the human the peptide Humanin is produced from the small
gene which is embedded as a gene-within-a-gene in the 16S ribosomal molecule of the mitochondrial DNA (mtDNA). The peptide itself appears to be significant in the prevention of cell death in many tissues and improve cognition in animal models. By using simple data mining techniques, it is possible to show that 99.4% of the human
sequences in the GenBank database are unaffected by mutations. However, in other vertebrates, pseudogenization of the Humanin gene is a common feature; occurring apparently randomly in some species and not others. The persistence, or loss, of a functional
gene may be an important factor in laboratory animals, especially if they are being used as animal models in studies of Alzheimer's disease (AD). The exact reason why
underwent pseudogenization in some vertebrate species during their evolution remains to be determined. This study was originally planned to review the available information about
and it was a surprise to be able to show that pseudogenization has occurred in a gene in the mtDNA and is not restricted solely to chromosomal genes.