International journal of oncology, 2015-08, Vol.47 (2), p.573-582
2015
Details
- Autor(en) / Beteiligte
- Titel
- Sulphur alters NFκB-p300 cross-talk in favour of p53-p300 to induce apoptosis in non-small cell lung carcinoma
- Ist Teil von
- International journal of oncology, 2015-08, Vol.47 (2), p.573-582
- Ort / Verlag
- Greece: D.A. Spandidos
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Adverse side effects of chemotherapy during cancer treatment have shifted considerable focus towards therapies that are not only targeted but are also devoid of toxic side effects. We evaluated the antitumorigenic activity of sulphur, and delineated the molecular mechanisms underlying sulphur-induced apoptosis in non-small cell lung carcinoma (NSCLC) cells. A search for the underlying mechanism revealed that the choice between the two cellular processes, NFκBp65-mediated survival and p53-mediated apoptosis, was decided by the competition for a limited pool of transcriptional coactivator protein p300 in NSCLC cells. In contrast, sulphur inhibited otherwise upregulated survival signaling in NSCLC cells by perturbing the nuclear translocation of p65NFκB, its association with p300 histone acetylase, and subsequent transcription of Bcl-2. Under such anti-survival condition, induction of p53-p300 cross-talk enhanced the transcriptional activity of p53 and intrinsic mitochondrial death cascade. Overall, the findings of this preclinical study clearly delineated the molecular mechanism underlying the apoptogenic effect of the non-toxic homeopathic remedy, sulphur, in NSCLC cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1019-6439eISSN: 1791-2423DOI: 10.3892/ijo.2015.3061Titel-ID: cdi_proquest_journals_1932308744
- Format
- –
- Schlagworte
- Antineoplastic Agents - pharmacology, Apoptosis, Bax, Bcl-2, Cancer, Cancer therapies, Carcinoma, Non-Small-Cell Lung - drug therapy, Carcinoma, Non-Small-Cell Lung - genetics, Carcinoma, Non-Small-Cell Lung - metabolism, Care and treatment, Cell cycle, Cell Line, Tumor, Cell Survival - drug effects, Chemotherapy, Complications and side effects, Deoxyribonucleic acid, DNA, Drug Evaluation, Preclinical, Drug resistance, E1A-Associated p300 Protein - genetics, E1A-Associated p300 Protein - metabolism, Gene expression, Gene Expression Regulation, Neoplastic - drug effects, Health aspects, homeopathy, Humans, Lung cancer, Lung cancer, Non-small cell, Lung Neoplasms - drug therapy, Lung Neoplasms - genetics, Lung Neoplasms - metabolism, Neuroblastoma, NF-kappa B - genetics, NF-kappa B - metabolism, NFκB, p300, p53, Signal Transduction - drug effects, Studies, Sulfur, Sulfur - pharmacology, sulphur, Transcription factors, Tumor Suppressor Protein p53 - genetics, Tumor Suppressor Protein p53 - metabolism