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This paper is concerned with the analysis and integrated design of a type of observer-based fault detection (FD) system for general nonlinear processes. To this end, the existence and design condition for this type of nonlinear observer-based FD systems is first introduced. In this context, the integrated design scheme is investigated by dealing with the design condition with the aid of Takagi-Sugeno (T-S) fuzzy dynamic modeling technique. To be specific, the universal T-S fuzzy observer-based residual generator is developed via fuzzy Lyapunov functions. Subsequently, an integrated observer-based FD scheme is proposed with an embedded dynamic threshold, which is generated to meet the real-time FD requirements from industrial processes. In the end, a numerical example and case simulation study on a continuous stirred tank heater process are performed to show the application of the proposed method.