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BibTeX
Interaction of single‐walled carbon nanotubes and saxitoxin: Ab initio simulations and biological responses in hippocampal cell line HT‐22
Environmental toxicology and chemistry, 2017-07, Vol.36 (7), p.1728-1737
Ramos, Patrícia
Schmitz, Marcos
Filgueira, Daza
Votto, Ana Paula
Durruthy, Michael
Gelesky, Marcos
Ruas, Caroline
Yunes, João
Tonel, Mariana
Fagan, Solange
Monserrat, José
2017
Details
Autor(en) / Beteiligte
Ramos, Patrícia
Schmitz, Marcos
Filgueira, Daza
Votto, Ana Paula
Durruthy, Michael
Gelesky, Marcos
Ruas, Caroline
Yunes, João
Tonel, Mariana
Fagan, Solange
Monserrat, José
Titel
Interaction of single‐walled carbon nanotubes and saxitoxin: Ab initio simulations and biological responses in hippocampal cell line HT‐22
Ist Teil von
Environmental toxicology and chemistry, 2017-07, Vol.36 (7), p.1728-1737
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Saxitoxins (STXs) are potent neurotoxins that also induce cytotoxicity through the generation of reactive oxygen species. Carbon nanotubes (CNTs) are nanomaterials that can promote a Trojan horse effect, facilitating the entry of toxic molecules to cells when adsorbed to nanomaterials. The interaction of pristine single‐walled (SW)CNTs and carboxylated (SWCNT‐COOH) nanotubes with STX was evaluated by ab initio simulation and bioassays using the cell line HT‐22. Cells (5 × 104 cells/mL) were exposed to SWCNT and SWCNT‐COOH (5 μg mL−1), STX (200 μg L−1), SWCNT+STX, and SWCNT‐COOH+STX for 30 min or 24 h. Results of ab initio simulation showed that the interaction between SWCNT and SWCNT‐COOH with STX occurs in a physisorption. The interaction of SWCNT+STX induced a decrease in cell viability. Cell proliferation was not affected in any treatment after 30 min or 24 h of exposure (p > 0.05). Treatment with SWCNT‐COOH induced high reactive oxygen species levels, an effect attenuated in SWCNT‐COOH+STX treatment. In terms of cellular oxygen consumption, both CNTs when coexposed with STX antagonize the toxin effect. Based on these results, it can be concluded that the results obtained in vitro corroborate the semiempirical evidence found using density functional theory ab initio simulation. Environ Toxicol Chem 2017;36:1728–1737. © 2016 SETAC
Sprache
Englisch
Identifikatoren
ISSN: 0730-7268
eISSN: 1552-8618
DOI: 10.1002/etc.3544
Titel-ID: cdi_proquest_journals_1914157028
Format
–
Schlagworte
Bioassays
,
Carbon nanotubes
,
Carboxylic Acids - chemistry
,
Cell Line
,
Cell proliferation
,
Cell Proliferation - drug effects
,
Cell Survival - drug effects
,
Cell viability
,
Cytotoxicity
,
Density functional theory
,
Exposure
,
Hippocampus
,
Hippocampus - cytology
,
Hippocampus - drug effects
,
Hippocampus - metabolism
,
HT‐22 cell
,
Humans
,
In vitro methods and tests
,
Nanomaterials
,
Nanotechnology
,
Nanotubes
,
Nanotubes, Carbon - chemistry
,
Nanotubes, Carbon - toxicity
,
Neurotoxins
,
Oxygen
,
Oxygen consumption
,
Reactive oxygen species
,
Reactive Oxygen Species - metabolism
,
Saxitoxin
,
Saxitoxin - chemistry
,
Saxitoxin - toxicity
,
Simulation
,
Single wall carbon nanotubes
,
Spectroscopy, Fourier Transform Infrared
,
Toxicity
,
Toxins
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