Details

Autor(en) / Beteiligte

• Natte, Kishore
• Jagadeesh, Rajenahally V.
• He, Lin
• Rabeah, Jabor
• Chen, Jianbin
• Taeschler, Christoph
• Ellinger, Stefan
• Zaragoza, Florencio
• Neumann, Helfried
• Brückner, Angelika
• Beller, Matthias

Titel

Palladium-Catalyzed Trifluoromethylation of (Hetero)Arenes with CF3Br

Ist Teil von

• Angewandte Chemie International Edition, 2016-02, Vol.55 (8), p.2782-2786

Auflage

International ed. in English

Ort / Verlag

Weinheim: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The CF3 group is an omnipresent motif found in many pharmaceuticals, agrochemicals, catalysts, materials, and industrial chemicals. Despite well‐established trifluoromethylation methodologies, the straightforward and selective introduction of such groups into (hetero)arenes using available and less expensive sources is still a major challenge. In this regard, the selective synthesis of various trifluoromethyl‐substituted (hetero)arenes by palladium‐catalyzed C−H functionalization is herein reported. This novel methodology proceeds under comparably mild reaction conditions with good regio‐ and chemoselectivity. As examples, trifluoromethylations of biologically important molecules, such as melatonin, theophylline, caffeine, and pentoxifylline, are showcased. A cheaper source: A general and reliable palladium‐catalyzed method for the synthesis of trifluoromethylated (hetero)arenes using CF3Br has been developed. The products are isolated in good yields and the reaction proceeds under comparably mild reaction conditions with good regio‐ and chemoselectivity.