Details

Autor(en) / Beteiligte

• Silchenko, A. S.
• Imbs, T. I.
• Zvyagintseva, T. N.
• Fedoreyev, S. A.
• Ermakova, S. P.

Titel

Brown Alga Metabolites – Inhibitors of Marine Organism Fucoidan Hydrolases

Ist Teil von

• Chemistry of natural compounds, 2017-03, Vol.53 (2), p.345-350

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Fucoidan hydrolase inhibitors were discovered for the first time. Metabolites in the aqueous EtOH extract of Fucus evanescens inhibited specifically the activity of enzymes involved in catabolism of brown-alga polysaccharides, i.e., fucoidanases (recombinant FFA from the marine bacterium Formosa algae KMM 3553T and PPF from the marine mollusk Patinopecten yessoensis) and glycosidases (recombinant α-L-fucosidase FucFa from F. algae and β-D-glucosidase G-II from the marine mollusk Littorina sitkana). The purified fucophlorethol fraction isolated from this extract inhibited recombinant fucoidanase FFA in the concentration range 10–50 μg/mL.