Details

Autor(en) / Beteiligte

• S Galdo Novo
• Malirat, V
• Maradei, ED
• Espinoza, A M
• Smitsaart, E
• Pedemonte, A R
• Mattion, N
• Bergmann, I E

Titel

Antigenic and immunogenic spectrum of foot-and-mouth disease vaccine strain O1Campos against representative viruses of topotypes that circulated in Asia over the past decade

Ist Teil von

• Vaccine, 2017-04, Vol.35 (18), p.2303

Ort / Verlag

Kidlington: Elsevier Limited

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Identifying vaccine strains to control outbreaks of foot-and-mouth disease virus that could spread to new regions is essential for contingency plans. This is the first report on the antigenic/immunogenic relationships of the South American O1/Campos vaccine strain with representative isolates of the three currently active Asian type O topotypes. Virus neutralization tests using O1/Campos post-vaccination sera derived from cattle and pigs predicted for both species acceptable cross-protection, even after single vaccination, established by r1 values and by expectancy of protection using monovalent or polyvalent vaccines. The results indicate that effective oil vaccines containing the O1/Campos strain can be used against Asian isolates, expanding the scope of O1/Campos strain included in vaccine banks to control emergencies caused by Asian viruses, even on single-dose vaccination, and to cover the need of effective vaccines in Asia during systematic vaccination.