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A series of novel aryl ureides were synthesized based on oxadiazoles and different substituted aromatic amines. The intermediate amine, (3-(
2H
-chromen-3-yl)-1,2,4-oxadiazol-5-yl)methanamines (
6a
) was reacted with aromatic amines in presence of triphosgene to obtain the urea derivatives
7a
–
d
and
7e
–
i
in high yields. The structures of all the intermediates and the final urea derivatives were established by IR, NMR and mass spectrometry data. The antibacterial activity of synthesized compounds was evaluated against two gram-negative bacteria namely
Escherichia coli
and
Pseudomonas aeroginosa
and it was observed that the urea derivatives
7a
and
7i
were promising antibacterial agents.