Details

Autor(en) / Beteiligte

• Zakharenko, A. L.
• Luzina, O. A.
• Sokolov, D. N.
• Zakharova, O. D.
• Rakhmanova, M. E.
• Chepanova, A. A.
• Dyrkheeva, N. S.
• Lavrik, O. I.
• Salakhutdinov, N. F.

Titel

Usnic acid derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1

Ist Teil von

• Russian journal of bioorganic chemistry, 2017, Vol.43 (1), p.84-90

Ort / Verlag

Moscow: Pleiades Publishing

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The synthesis of (+)-usnic acid derivatives is described. The derivatives contain one or two cyano groups, connected to the acetophenone fragment of dibenzofuran core by linkers of different length and character, or some other modifications. The influence of these compounds on the activity of recombinant human tyrosyl-DNA phosphodiesterase 1 and MCF-7 tumor cells’ viability has been estimated. The data indicate a distinct dependence of functional characteristics of the compounds on their structure.