Details

Autor(en) / Beteiligte

• Zierler, Sally
• Rothman, Kenneth J

Titel

Congenital Heart Disease in Relation to Maternal Use of Bendectin and Other Drugs in Early Pregnancy

Ist Teil von

• The New England journal of medicine, 1985-08, Vol.313 (6), p.347-352

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1985

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• To clarify the association of Bendectin and other drugs used in early pregnancy with the occurrence of congenital heart disease, we interviewed 298 mothers of children with congenital heart disease and 738 mothers of healthy controls. Differential recall of drug use by mothers of affected children and mothers of controls was evaluated by comparison of information collected by interview with that recorded in the prenatal record. Data derived from maternal interviews were generally consistent with the record data. Reported Bendectin use was minimally associated with congenital heart disease (prevalence odds ratio, 1.1; 90 per cent confidence interval, 0.8 to 1.5). The data from this study were consistent with previously reported associations of other drugs with congenital heart disease. In particular, aspirin use in early pregnancy was associated with about a twofold increase in the frequency of defects in septation of the truncus arteriosus (prevalence odds ratio, 2.1; 90 per cent confidence interval, 1.1 to 3.9). (N Engl J Med 1985; 313:347–52.) IN 1979 Rothman et al. 1 reported an estimated 80 per cent increase in the prevalence of congenital heart disease among offspring of women who recalled use in early pregnancy of Bendectin, an antinausea preparation containing doxylamine succinate, dicyclomine hydrochloride (removed in 1977), and pyridoxine hydrochloride. The finding was considered by the investigators to be incidental and highly tentative, since the data on Bendectin were derived from a nonspecific question about drug use during pregnancy. Among the noncausal explanations was the possibility that mothers of offspring with congenital heart disease could have recalled Bendectin use more frequently than mothers of healthy . . .