Details

Autor(en) / Beteiligte

• Mathias, Rasika A
• Chavan, Sameer
• Boorgula, Meher
• Cookson, William O.C., MD, DPhil
• Willis-Owen, Saffron
• Rafaels, Nicholas M
• Hanifin, Jon M., MD, FAAAAI
• Paller, Amy
• Schneider, Lynda C., MD, FAAAAI
• Gallo, Richard, MD, PhD
• Guttman-Yassky, Emma, MD, PhD
• Ong, Peck Y., MD, FAAAAI
• Ruczinski, Ingo
• Beaty, Terri
• Gao, Li
• Beck, Lisa A., MD, FAAAAI
• Moffat, Miriam
• Leung, Donald Y.M., MD, PhD, FAAAAI
• Barnes, Kathleen C., PhD, FAAAAI

Titel

Whole Genome Sequencing Identifies Four Novel Variants in the Epidermal Differentiation Complex That Increase Risk and Severity for Atopic Dermatitis

Ist Teil von

• Journal of allergy and clinical immunology, 2017-02, Vol.139 (2), p.AB85-AB85

Ort / Verlag

St. Louis: Elsevier Inc

Erscheinungsjahr

2017

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Methods We use whole genome sequencing on 493 European American AD subjects (average age = 26, average severity measured by EASI score = 14.5) and 237 non-atopic controls in the Atopic Dermatitis Research Network (ADRN) study to test for association with single nucleotide polymorphisms (SNPs) in the EDC as risk determinants of AD as well as severity of disease.