Details

Autor(en) / Beteiligte

• Yang, Si‐Yi
• Han, Wen‐Yong
• Zhang, Ding‐Lei
• Zhou, Xiao‐Jian
• Bai, Mei
• Cui, Bao‐Dong
• Wan, Nan‐Wei
• Yuan, Wei‐Cheng
• Chen, Yong‐Zheng

Titel

Synthesis of Phenanthridines through Palladium‐Catalyzed Cascade Reaction of 2‐Halo‐N‐Ms‐arylamines with Benzyl Halides/Sulfonates

Ist Teil von

• European journal of organic chemistry, 2017-02, Vol.2017 (5), p.996-1003

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An efficient palladium‐catalyzed nucleophilic substitution/C–H activation/aromatization cascade reaction between readily available 2‐halo‐N‐Ms‐arylamines (Ms = methanesulfonyl) and benzyl halides/sulfonates has been described. A wide variety of phenanthridines were synthesized in a one‐pot fashion in moderate to high yields (37–86 %). Notably, this method provides a straightforward, facile approach for the synthesis of phenanthridines. The practicality was further substantiated by successfully carrying out a gram‐scale preparation. A facile and efficient palladium‐catalyzed nucleophilic substitution/C–H activation/aromatization cascade reaction for the construction of phenanthridines has been explored. This work provides a practical protocol to obtain phenanthridines in moderate to high yields (37–86 %) from readily available 2‐halo‐N‐Ms‐arylamines (Ms = methanesulfonyl) and benzyl halide/sulfonate substrates.