Details

Autor(en) / Beteiligte

• Jhuang, Huei-Shu
• Reddy, Daggula Mallikarjuna
• Chen, Te-Hsuan
• Lee, Chin-Fa

Titel

DTBP/TBHP-Promoted Hydroacylation of Unactivated Alkenes

Ist Teil von

• Asian journal of organic chemistry, 2016-12, Vol.5 (12), p.1452-1456

Ort / Verlag

Weinheim: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Di‐tert‐butyl peroxide (DTBP)‐promoted intermolecular hydroacylation reaction of alkenes with aromatic aldehydes that provides ketones is described. In this study, 4‐chromanones were formed when 2‐(allyloxy)benzaldehydes were treated with tert‐butyl hydroperoxide (TBHP). The reactions were performed under solvent‐ and metal‐free conditions. Reactions proceeded through the generation of acyl radicals, followed by the reaction with alkenes. Remarkably, not only terminal alkenes but also internal alkenes could serve as the starting materials for intramolecular hydroacylation reaction. Radical process: A di‐tert‐butyl peroxide (DTBP)‐promoted intermolecular hydroacylation reaction of alkenes with aromatic aldehydes that provides ketones is described. In this study, 4‐chromanones were formed when 2‐(allyloxy)benzaldehydes were treated with tert‐butyl hydroperoxide (TBHP). The reactions were performed under solvent‐ and metal‐free conditions. Reactions proceeded through the generation of acyl radicals, followed by the reaction with alkenes. Remarkably, not only terminal alkenes but also internal alkenes could serve as the starting materials for intramolecular hydroacylation reaction.