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Cardiovascular Toxic Effects of Targeted Cancer Therapies
Ist Teil von
The New England journal of medicine, 2016-10, Vol.375 (15), p.1457-1467
Ort / Verlag
United States: Massachusetts Medical Society
Erscheinungsjahr
2016
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Agents targeting signaling pathways in cancer cells are less specific than advertised. A number of these agents induce cardiovascular toxic effects ranging from decreased ejection fraction to atrial arrhythmias.
The field of cardio-oncology represents the intersection of cancer and cardiovascular disease. This clinical specialty is focused on the cardiovascular care of patients with cancer and has expanded owing to the emergence of new targeted oncology therapies. Although these treatments have dramatically changed the natural course of many cancers, they may result in cardiovascular, thrombotic, or metabolic complications, which can be manifested either during the course of therapy or after completion of treatment. This article focuses on the cardiovascular toxic effects that may be associated with these new targeted cancer therapies and provides a broad overview of this emerging field. . . .