Details

Autor(en) / Beteiligte

• Li, Jialiang
• Wan, Wen
• Ma, Guobin
• Chen, Yunrong
• Hu, Qingyang
• Kang, Kai
• Jiang, Haizhen
• Hao, Jian

Titel

Silver-Mediated C-H Difluoromethylation of Arenes

Ist Teil von

• European journal of organic chemistry, 2016-10, Vol.2016 (28), p.4916-4921

Ort / Verlag

Weinheim: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The first AgI‐mediated C–H ethoxycarbonyl difluoromethylation with TMSCF2COOEt (TMS = trimethylsilyl) has been developed. The radical difluoromethylation proceeds smoothly to give the difluoromethylated arenes in moderate to high yields with Friedel–Crafts‐type regioselectivity. Mechanistic studies indicate that the innate C–H difluoromethylation proceeds through an electrophilic radical‐type pathway. The first AgI‐mediated C–H difluoromethylation of arenes has been developed through an electrophilic radical‐type pathway.