Details

Autor(en) / Beteiligte

• Thippeswamy, R
• Patil, S
• Shashidara, H P
• Satheesh, C T
• Vittal, H
• Mishra, S

Titel

Eribulin mesylate in Indian patients: A single center experience

Ist Teil von

• Indian journal of cancer, 2015-07, Vol.52 (3), p.297

Ort / Verlag

India: Medknow Publications and Media Pvt. Ltd

Erscheinungsjahr

2015

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• Eribulin mesylate is the latest addition in the armamentarium of management of metastatic breast cancer (MBC) with a unique mechanism of action. Although the multicentric EMBRACE trial suggests significant overall survival benefit from this novel drug, its effectiveness in Indian population is yet to be evaluated. Presented here is a single center experience of eight patients who were administered eribulin for MBC. Patients had received a median of 3 prior chemotherapies before eribulin administration. The median dose of eribulin therapy was 5 cycles (range: 2-6 cycles). The objective response rate was 75% (CR in one and PR in five out of eight patients). Response was seen across all subtypes of patients. Eribulin was well tolerated. No serious adverse events were reported. Eribulin conferred good response rates with satisfactory tolerability profile in Indian patients. Its use in earlier lines and in combination with other drugs may achieve deeper and longer responses.