Details

Autor(en) / Beteiligte

• Liu, Peijun
• Guo, Jiajing
• Wei, Wentao
• Liu, Xiaozu
• Sun, Pinghua

Titel

Iodine-Catalyzed Oxidation of N-Substituted Indoles by using Chloramine-B: A Facile and Practical Approach to Isatins

Ist Teil von

• European Journal of Organic Chemistry, 2016-04, Vol.2016 (12), p.2105-2109

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An efficient method for the iodine‐catalyzed oxidation of N‐substituted indoles by using chloramine‐B under mild reaction conditions was explored. This reaction was found to be tolerant to a variety of functional groups and provided the corresponding isatins in moderate to excellent yields. In addition, application of this method to the one‐pot synthesis of 3‐hydroxyoxindole and N‐methylisatin oxime was realized. The molecular‐iodine‐catalyzed oxidation of N‐substituted indoles by using chloramine‐B for the efficient construction of isatins is developed. This method is mild, operates under ambient conditions, uses a catalytic amount of iodine, and has a broad substrate scope; MOM = methoxymethyl, Bn = benzyl.