Details

Autor(en) / Beteiligte

• Oddy, Wendy H
• Herbison, Carly E
• Jacoby, Peter
• Ambrosini, Gina L
• O'Sullivan, Therese A
• Ayonrinde, Oyekoya T
• Olynyk, John K
• Black, Lucinda J
• Beilin, Lawrence J
• Mori, Trevor A
• Hands, Beth P
• Adams, Leon A

Titel

The Western dietary pattern is prospectively associated with nonalcoholic fatty liver disease in adolescence

Ist Teil von

• The American journal of gastroenterology, 2013-05, Vol.108 (5), p.778-785

Ort / Verlag

United States: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Poor dietary habits have been implicated in the development of nonalcoholic fatty liver disease (NAFLD); however, little is known about the role of specific dietary patterns in the development of NAFLD. We examined prospective associations between dietary patterns and NAFLD in a population-based cohort of adolescents. Participants in the Western Australian Pregnancy Cohort (Raine) Study completed a food frequency questionnaire at 14 years and had liver ultrasound at 17 years (n=995). Healthy and Western dietary patterns were identified using factor analysis and all participants received a z-score for these patterns. Prospective associations between the dietary pattern scores and risk of NAFLD were analyzed using multiple logistic regression. NAFLD was present in 15.2% of adolescents. A higher Western dietary pattern score at 14 years was associated with a greater risk of NAFLD at 17 years (odds ratio (OR) 1.59; 95% confidence interval (CI) 1.17-2.14; P<0.005), although these associations were no longer significant after adjusting for body mass index at 14 years. However, a healthy dietary pattern at 14 years appeared protective against NAFLD at 17 years in centrally obese adolescents (OR 0.63; 95% CI 0.41-0.96; P=0.033), whereas a Western dietary pattern was associated with an increased risk of NAFLD. A Western dietary pattern at 14 years in a general population sample was associated with an increased risk of NAFLD at 17 years, particularly in obese adolescents. In centrally obese adolescents with NAFLD, a healthy dietary pattern may be protective, whereas a Western dietary pattern may increase the risk.