Details

Autor(en) / Beteiligte

• Jun, Li
• Fanghong, Lu
• Yingxin, Zhao
• Zhendong, Liu

Titel

Impact of tumour necrosis factor-a on ambulatory arterial stiffness index in prehypertensives

Ist Teil von

• Heart (British Cardiac Society), 2011-10, Vol.97 (Suppl 3), p.A199-A199

Ort / Verlag

London: BMJ Publishing Group Ltd and British Cardiovascular Society

Erscheinungsjahr

2011

Quelle

BMJ Journals Archiv - DFG Nationallizenzen

Beschreibungen/Notizen

• Objective To investigate the impact of tumour necrosis factor-a on ambulatory arterial stiffness index in prehypertensives. Methods One hundred normotensives and one hundred and five prehypertensives were recruited, while one hundred and ten hypertensives were enrolled. 24 h ambulatory blood pressure monitoring (ABPM) was carried out in the three groups, respectively, and ambulatory arterial stiffness index (AASI) was computed. Tumour necrosis factor-a (TNF-a) was measured using radioimmunity kits. Results Tumour necrosis factor-a and ambulatory arterial stiffness index in prehypertensives (44.21±9.81 pg/ml, 0.42±0.13), were higher than that in normotensives (26.91±12.35 pg/ml, 0.36±0.15), while lower than that in hypertensives (59.74±23.38 pg/ml, 0.49±0.12). Pearson correlation analysis showed that the level of tumour necrosis factor-a was positively correlated with ambulatory arterial stiffness index in prehypertensives (r=0.513, p<0.01). Multiple linear stepwise regression analysis showed that ambulatory arterial stiffness index still correlated with tumour necrosis factor-a (b=0.272, p<0.01). Conclusion Ambulatory arterial stiffness index was correlated with tumour necrosis factor-a. Inflammation was relevant to the development of arterial stiffness in prehypertensives.