Details

Autor(en) / Beteiligte

• Büning, J
• Homann, N
• von Smolinski, D
• Borcherding, F
• Noack, F
• Stolte, M
• Kohl, M
• Lehnert, H
• Ludwig, D

Titel

Helminths as governors of inflammatory bowel disease

Ist Teil von

• Gut, 2008-08, Vol.57 (8), p.1182-1183

Ort / Verlag

England: BMJ Publishing Group Ltd and British Society of Gastroenterology

Erscheinungsjahr

2008

Quelle

BMJ Journals Archiv - DFG Nationallizenzen

Beschreibungen/Notizen

• In experimental models of murine colitis, helminths have been demonstrated to protect against colonic inflammation. 2 Regulatory T cells (Treg) were suggested to be responsible for this protective effect. 2 In our patient we aimed at elucidating differences in the mucosal infiltration by Treg between helminthosis and subsequent active ulcerative colitis. RNA extraction, reverse transcription and real-time quantitative polymerase chain reaction (PCR) were carried out as described previously. 5 6 We found mRNA levels of transforming growth factor-β (TGF-β) and interleukin 4 (IL4) to be strongly upregulated during colonisation by E vermicularis compared to ulcerative colitis.