Details

Autor(en) / Beteiligte

• Xie, Yingda L
• Rosen, Lindsey B
• Sereti, Irini
• Barber, Daniel L
• Chen, Ray Y
• Hsu, Denise C
• Qasba, S Sonia
• Zerbe, Christa S
• Holland, Steven M
• Browne, Sarah K

Titel

Severe Paradoxical Reaction During Treatment of Disseminated Tuberculosis in a Patient With Neutralizing Anti-IFN[Gamma] Autoantibodies

Ist Teil von

• Clinical infectious diseases, 2016-03, Vol.62 (6), p.770

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2016

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Interferon-gamma (IFNy) neutralizing autoantibodies are associated with disseminated nontuberculous mycobacterial infections. We report a previously healthy Thai woman with disseminated tuberculosis and high-titer IFNy-neutralizing autoantibodies, who developed a severe inflammatory reaction during anti-tuberculosis treatment. IFNy contributes to host control of tuberculosis but appears inessential for tuberculosis paradoxical reactions.