Details

Autor(en) / Beteiligte

• Kaledin, V. I.
• Il’nitskaya, S. I.
• Popova, N. A.
• Bogdanova, L. A.

Titel

Suppression of Sulfoconjugation Reduces the Protective Effect of Ortho-Aminoazotoluene on Hepatocarcinogenesis Induced by Diethylnitrosamine in Mice

Ist Teil von

• Bulletin of experimental biology and medicine, 2014-07, Vol.157 (3), p.368-370

Ort / Verlag

Boston: Springer US

Erscheinungsjahr

2014

Quelle

SpringerLink

Beschreibungen/Notizen

• The effects of ortho -aminoazotoluene on carcinogenic activity of diethylnitrosamine were studied in CBA and ICR mice. Injection of ortho -aminoazotoluene before and after diethylnitrosamine led to a signifi cant reduction of its anticarcinogenic effect, judging from signifi - cantly lower level of liver tumors. Pentachlorophenol, inhibitor of sulfotransferase (catalyzing the terminal stage of ortho -aminoazotoluene metabolic activity), stimulated its carcinogenic effect on mouse liver. On the other hand, pentachlorophenol reduced the protective effect of ortho -aminoazotoluene on diethylnitrosamine-induced hepatocarcinogenesis in mice. Presumably, the carcinogenic and anticarcinogenic effects of ortho -aminoazotoluene were realized by its initial form or intermediate (non-sulfated) metabolites.