Details

Autor(en) / Beteiligte

• Korbad, Balaji L.
• Lee, Sang-Hyeup

Titel

Synthesis of N,N-Disubstituted 3-Amino-1,4-diynes and 3-Amino-1-ynes by Addition of Alkynyldimethylaluminum Reagents to N,N-Disubstituted Formamides and N,O-Acetals

Ist Teil von

• European journal of organic chemistry, 2014-08, Vol.2014 (23), p.5089-5095

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A wide range of alkynyldimethylaluminum reagents, which were derived from terminal alkynes and trimethylaluminum, underwent a double addition to N,N‐disubstituted formamides and their acetals to provide the corresponding N,N‐disubstituted 3‐amino‐1,4‐diynes in moderate to excellent yields. Also, these reagents smoothly underwent the addition to N,O‐acetals to give the corresponding N,N‐disubstituted 3‐amino‐1‐ynes in excellent yields. A range of alkynyldimethylaluminum reagents were added to N,N‐disubstituted formamides and the their acetals to provide the corresponding N,N‐disubstituted 3‐amino‐1,4‐diynes. Also, these reagents smoothly underwent the addition to N,O‐acetals to give the corresponding N,N‐disubstituted 3‐amino‐1‐ynes.