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Autor(en) / Beteiligte
Titel
In Vivo Longitudinal ^sup 1^H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1 T
Ist Teil von
  • Neurochemical research, 2015-12, Vol.40 (12), p.2639
Ort / Verlag
New York: Springer Nature B.V
Erscheinungsjahr
2015
Link zum Volltext
Quelle
SpringerNature Journals
Beschreibungen/Notizen
  • Issue Title: Special Issue in Honor of Gerald A. Dienel In vivo ^sup 1^H MR spectroscopy allows the non invasive characterization of brain metabolites and it has been used for studying brain metabolic changes in a wide range of neurodegenerative diseases. The prion diseases form a group of fatal neurodegenerative diseases, also described as transmissible spongiform encephalopathies. The mechanism by which prions elicit brain damage remains unclear and therefore different transgenic mouse models of prion disease were created. We performed an in vivo longitudinal ^sup 1^H MR spectroscopy study at 14.1 T with the aim to measure the neurochemical profile of Prnp -/- and PrP^sub [Delta]32-121^ mice in the hippocampus and cerebellum. Using high-field MR spectroscopy we were able to analyze in details the in vivo brain metabolites in Prnp -/- and PrP^sub [Delta]32-121^ mice. An increase of myo-inositol, glutamate and lactate concentrations with a decrease of N-acetylaspartate concentrations were observed providing additional information to the previous measurements.
Sprache
Englisch
Identifikatoren
ISSN: 0364-3190
eISSN: 1573-6903
DOI: 10.1007/s11064-015-1643-9
Titel-ID: cdi_proquest_journals_1749606888
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