Details

Autor(en) / Beteiligte

• Rothenberg, Marc E., MD, PhD
• Bousquet, Jean, MD

Titel

News Beyond Our Pages

Ist Teil von

• Journal of allergy and clinical immunology, 2015-12, Vol.136 (6), p.1429-1430

Ort / Verlag

St. Louis: Elsevier Limited

Erscheinungsjahr

2015

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The mechanistic basis for MC activation in patients with this disorder is unknown, which led Liu et al (J Immunol 2015;195:3537-45) to determine that patients with AERD have markedly increased epithelial expression of the alarmin-like cytokine IL-33 in nasal polyps compared with that seen in polyps from aspirin-tolerant control subjects. [...]the authors show that a murine model of AERD, lacking microsomal prostaglandin E2 synthase (ptges-/- mice), shows a similar upregulation of IL-33 protein in the airway epithelium, along with marked eosinophilic bronchovascular inflammation. Furthermore, challenges of dust mite-primed ptges-/- mice with lysine aspirin induce IL-33-dependent MC activation and bronchoconstriction. [...]IL-33 is a component of a cysLT-driven innate type 2 immune response that drives pathogenic MC activation and contributes substantially to AERD pathogenesis.