Details

Autor(en) / Beteiligte

• Richards, Duncan B
• Cookson, Louise M
• Berges, Alienor C
• Barton, Sharon V
• Lane, Thirusha
• Ritter, James M
• Fontana, Marianna
• Moon, James C
• Pinzani, Massimo
• Gillmore, Julian D
• Hawkins, Philip N
• Pepys, Mark B

Titel

Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component

Ist Teil von

• The New England journal of medicine, 2015-09, Vol.373 (12), p.1106-1114

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A two-step process, in which circulating levels of amyloid P are reduced and then anti–serum amyloid P antibody is given to activate macrophage clearance mechanisms of tissue deposits, appears to reduce amyloid deposits in liver and some other organs. In systemic amyloidosis, the extracellular deposition of normally soluble plasma proteins as insoluble amyloid fibrils damages the structure and function of tissues and organs. 1 Current treatment consists of support or replacement of failing organs and measures to reduce the abundance of the amyloid fibril precursor protein. 1 , 2 A sufficient reduction of precursor supply arrests the accumulation of amyloid and can reduce morbidity and mortality. However, amyloid regression is very slow and often does not occur at all, in contrast to the usually swift clearance of other extracellular debris and efficient tissue remodeling — for example, after trauma. At least 65% . . .