Details

Autor(en) / Beteiligte

• He, Wen-Fei
• Liang, Lin-Fu
• Cai, You-Sheng
• Gao, Li-Xin
• Li, Yu-Fen
• Li, Jia
• Liu, Hai-Li
• Guo, Yue-Wei

Titel

Brominated polyunsaturated lipids with protein tyrosine phosphatase-1B inhibitory activity from Chinese marine sponge Xestospongia testudinaria

Ist Teil von

• Journal of asian natural products research, 2015-08, Vol.17 (8), p.861-866

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2015

Quelle

Taylor & Francis

Beschreibungen/Notizen

• A new brominated polyunsaturated lipid, methyl (E,E)-14,14-dibromo-4,6,13-tetradecatrienoate (1), along with three known related analogues (2-4), were isolated from the Et 2 O-soluble portion of the acetone extract of Chinese marine sponge Xestospongia testudinaria treated with diazomethane. The structure of the new compound was elucidated by detailed spectroscopic analysis and by comparison with literature data. Compound 3 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of type II diabetes and obesity, with an IC 50 value of 5.30 ± 0.61 μM, when compared to the positive control oleanolic acid (IC 50  = 2.39 ± 0.26 μM).