Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Promiscuous T-cell responses to drugs and drug-haptens
Ist Teil von
Journal of allergy and clinical immunology, 2015-08, Vol.136 (2), p.474-476.e8
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2015
Quelle
MEDLINE
Beschreibungen/Notizen
Additional experiments found that T-cell proliferative responses (n = 5 clones) were detected consistently when antigen-presenting cells were pulsed with flucloxacillin for 24 to 48 hours (and after 4 hours, to a lesser extent; Fig E3). [...]flucloxacillin hapten-specific T cells predominate in patients with liver injury. [...]to date, the specific HLA alleles that interact with amoxicillin to activate T cells have not been defined. [...]antigen-presenting cells were generated from 10 HLA-mismatched donors expressing different HLA class I and HLA-DR alleles to patients with liver injury.