Journal of allergy and clinical immunology, 2015-08, Vol.136 (2), p.474-476.e8
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Promiscuous T-cell responses to drugs and drug-haptens
- Ist Teil von
- Journal of allergy and clinical immunology, 2015-08, Vol.136 (2), p.474-476.e8
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Additional experiments found that T-cell proliferative responses (n = 5 clones) were detected consistently when antigen-presenting cells were pulsed with flucloxacillin for 24 to 48 hours (and after 4 hours, to a lesser extent; Fig E3). [...]flucloxacillin hapten-specific T cells predominate in patients with liver injury. [...]to date, the specific HLA alleles that interact with amoxicillin to activate T cells have not been defined. [...]antigen-presenting cells were generated from 10 HLA-mismatched donors expressing different HLA class I and HLA-DR alleles to patients with liver injury.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0091-6749eISSN: 1097-6825DOI: 10.1016/j.jaci.2015.02.036Titel-ID: cdi_proquest_journals_1702718373
- Format
- –
- Schlagworte
- Allergy and Immunology, Amoxicillin - adverse effects, Anti-Bacterial Agents - adverse effects, Antigen-Presenting Cells - drug effects, Antigen-Presenting Cells - immunology, Antigen-Presenting Cells - pathology, Antigens, B-Lymphocytes - drug effects, B-Lymphocytes - immunology, B-Lymphocytes - pathology, CD4-Positive T-Lymphocytes - drug effects, CD4-Positive T-Lymphocytes - immunology, CD4-Positive T-Lymphocytes - pathology, CD8-Positive T-Lymphocytes - drug effects, CD8-Positive T-Lymphocytes - immunology, CD8-Positive T-Lymphocytes - pathology, Chemical and Drug Induced Liver Injury - etiology, Chemical and Drug Induced Liver Injury - genetics, Chemical and Drug Induced Liver Injury - immunology, Chemical and Drug Induced Liver Injury - pathology, Clavulanic Acid - adverse effects, Clone Cells, Cloning, Drugs, Experiments, Floxacillin - adverse effects, Gene Expression, Haptens - adverse effects, HLA Antigens - genetics, HLA Antigens - immunology, Humans, Liver, Lymphocyte Activation - drug effects, Lymphocytes, Patients, Peptides, Proteins, Rodents, Signal transduction, T cell receptors