Details

Autor(en) / Beteiligte

• Whelan, Timothy J
• Olivotto, Ivo A
• Parulekar, Wendy R
• Ackerman, Ida
• Chua, Boon H
• Nabid, Abdenour
• Vallis, Katherine A
• White, Julia R
• Rousseau, Pierre
• Fortin, Andre
• Pierce, Lori J
• Manchul, Lee
• Chafe, Susan
• Nolan, Maureen C
• Craighead, Peter
• Bowen, Julie
• McCready, David R
• Pritchard, Kathleen I
• Gelmon, Karen
• Murray, Yvonne
• Chapman, Judy-Anne W
• Chen, Bingshu E
• Levine, Mark N

Titel

Regional Nodal Irradiation in Early-Stage Breast Cancer

Ist Teil von

• The New England journal of medicine, 2015-07, Vol.373 (4), p.307-316

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Women with breast cancer who are undergoing breast-conserving surgery were assigned to receive whole-breast irradiation with or without regional nodal irradiation. At 10 years, disease-free survival in the nodal-irradiation group was improved but overall survival was not. Many women with early-stage breast cancer undergo breast-conserving surgery followed by whole-breast irradiation, which reduces the rate of local recurrence. 1 – 3 Radiotherapy to the chest wall and regional lymph nodes, termed regional nodal irradiation, which is commonly used after mastectomy in women with node-positive breast cancer who are treated with adjuvant systemic therapy, reduces locoregional and distant recurrence and improves overall survival. 4 – 6 An unanswered question is whether the addition of regional nodal irradiation to whole-breast irradiation after breast-conserving surgery has the same effect. Whole-breast irradiation may involve irradiation of the lower axillary and internal mammary lymph nodes. 7 However, regional . . .