Details

Autor(en) / Beteiligte

• Murlykina, Maryna V.
• Sakhno, Yana I.
• Desenko, Sergey M.
• Shishkina, Svetlana V.
• Shishkin, Oleg V.
• Sysoiev, Dmytro O.
• Kornet, Maryna N.
• Schols, Dominique
• Goeman, Jan L.
• Van der Eycken, Johan
• Van der Eycken, Erik V.
• Chebanov, Valentin A.

Titel

Study of the Chemoselectivity of Multicomponent Heterocyclizations Involving 3-Amino-1,2,4-triazole and Pyruvic Acids as Key Reagents, and Biological Activity of the Reaction Products

Ist Teil von

• European journal of organic chemistry, 2015-07, Vol.2015 (20), p.4481-4492

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2015

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Three‐component reactions involving 3‐amino‐1,2,4‐triazole, aldehydes, including salicylic aldehydes, and pyruvic acids were studied in detail. The reaction pathway and products of the heterocyclizations could be changed by variation of the reaction parameters. The broad antimicrobial activity of the products was also studied. Compound 9d showed specific anti‐influenza virus (A/H1N1) activity, with an IC50 of 0.57 μM and a CC50 of >100 μM. The chemoselectivity of switchable three‐component heterocyclizations involving 3‐amino‐1,2,4‐triazole, aldehydes, and pyruvic acids were studied. The antimicrobial and antiviral activity of the products was screened.