Advanced healthcare materials, 2015-07, Vol.4 (10), p.1526-1536
2015
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- Autor(en) / Beteiligte
- Titel
- A Near Infrared Light Triggered Hydrogenated Black TiO2 for Cancer Photothermal Therapy
- Ist Teil von
- Advanced healthcare materials, 2015-07, Vol.4 (10), p.1526-1536
- Ort / Verlag
- Germany: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2015
- Quelle
- Access via Wiley Online Library
- Beschreibungen/Notizen
- White TiO2 nanoparticles (NPs) have been widely used for cancer photodynamic therapy based on their ultraviolet light–triggered properties. To date, biomedical applications using white TiO2 NPs have been limited, since ultraviolet light is a well‐known mutagen and shallow penetration. This work is the first report about hydrogenated black TiO2 (H‐TiO2) NPs with near infrared absorption explored as photothermal agent for cancer photothermal therapy to circumvent the obstacle of ultraviolet light excitation. Here, it is shown that photothermal effect of H‐TiO2 NPs can be attributed to their dramatically enhanced nonradiative recombination. After polyethylene glycol (PEG) coating, H‐TiO2‐PEG NPs exhibit high photothermal conversion efficiency of 40.8%, and stable size distribution in serum solution. The toxicity and cancer therapy effect of H‐TiO2‐PEG NPs are relative systemically evaluated in vitro and in vivo. The findings herein demonstrate that infrared‐irradiated H‐TiO2‐PEG NPs exhibit low toxicity, high efficiency as a photothermal agent for cancer therapy, and are promising for further biomedical applications. Hydrogenated black TiO2 (H‐TiO2) nanoparticles with strong near infrared absorption are coated by polyethylene glycol (PEG) to form H‐TiO2‐PEG nanoparticles, and then explored as a novel cancer therapy agent. The findings demonstrate that near infrared‐triggered H‐TiO2‐PEG nanoparticles exhibit low toxicity, high efficiency for cancer therapy, and are promising for further biomedical applications.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2192-2640eISSN: 2192-2659DOI: 10.1002/adhm.201500273Titel-ID: cdi_proquest_journals_1696167860
- Format
- –
- Schlagworte
- Animals, Body Temperature - radiation effects, Cancer, Cancer therapies, Cell Line, Tumor, Cell Survival - drug effects, Cell Survival - radiation effects, Humans, Hydrogen - chemistry, hydrogenated black TiO2, Hydrogenation, Infrared Rays, MCF-7 Cells, Metal Nanoparticles - chemistry, Metal Nanoparticles - toxicity, Mice, Mice, Inbred BALB C, Neoplasms - drug therapy, Neoplasms - pathology, Photochemotherapy, photothermal therapy, Polyethylene Glycols - chemistry, Tissue Distribution - drug effects, Tissue Distribution - radiation effects, Titanium - chemistry, Transplantation, Heterologous, Ultraviolet radiation