Angewandte Chemie (International ed.), 2015-06, Vol.54 (27), p.7929
International ed. in English, 2015
Details
- Autor(en) / Beteiligte
- Titel
- Merging Photoredox and Nickel Catalysis: The Direct Synthesis of Ketones by the Decarboxylative Arylation of [alpha]-Oxo Acids
- Ist Teil von
- Angewandte Chemie (International ed.), 2015-06, Vol.54 (27), p.7929
- Auflage
- International ed. in English
- Ort / Verlag
- Weinheim: Wiley Subscription Services, Inc
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- The direct decarboxylative arylation of [alpha]-oxo acids has been achieved by synergistic visible-light-mediated photoredox and nickel catalysis. This method offers rapid entry to aryl and alkyl ketone architectures from simple [alpha]-oxo acid precursors via an acyl radical intermediate. Significant substrate scope is observed with respect to both the oxo acid and arene coupling partners. This mild decarboxylative arylation can also be utilized to efficiently access medicinal agents, as demonstrated by the rapid synthesis of fenofibrate.