Details

Autor(en) / Beteiligte

• San Roman, J. Alberto, MD, PhD
• Sánchez, Pedro L., MD, PhD
• Villa, Adolfo, MD, PhD
• Sanz-Ruiz, Ricardo, MD
• Fernandez-Santos, María Eugenia, PhD
• Gimeno, Federico, MD, PhD
• Ramos, Benigno, MD
• Arnold, Roman, MD, PhD
• Serrador, Ana, MD, PhD
• Gutiérrez, Hipólito, MD
• Martin-Herrero, Francisco, MD, PhD
• Rollán, María Jesús, MD, PhD
• Fernández-Vázquez, Felipe, MD, PhD
• López-Messa, Juan, MD, PhD
• Ancillo, Pablo, MD, PhD
• Pérez-Ojeda, German, MD, PhD
• Fernández-Avilés, Francisco, MD, PhD

Titel

Comparison of Different Bone Marrow–Derived Stem Cell Approaches in Reperfused STEMI

Ist Teil von

• Journal of the American College of Cardiology, 2015-06, Vol.65 (22), p.2372-2382

Ort / Verlag

New York: Elsevier Inc

Erscheinungsjahr

2015

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Abstract Background Stem cell–based therapy has emerged as a potential therapy in acute myocardial infarction (AMI). Although various approaches have been studied, intracoronary injection of bone marrow autologous mononuclear cells (BMMC) and the ability of granulocyte colony-stimulating factor (G-CSF) to mobilize endogenous cells have attracted the most attention. Objectives This study compares, for the first time, the efficacy of BMMC injection, G-CSF mobilization, and the combination of both with standard treatment. Methods On Day 1 after primary percutaneous coronary intervention, 120 patients were randomized to a 1) intracoronary BMMC injection; 2) mobilization with G-CSF; 3) both (BMMC injection plus G-CSF); or 4) conventional treatment (control group). G-CSF, 10 μg/kg/day subcutaneously, was started Day 1 and maintained for 5 days. BMMC injection was performed on Days 3 to 5. Our primary endpoint was absolute change in 12-month left ventricular ejection fraction (LVEF) and left ventricular end-systolic volume (LVESV) relative to baseline measured by cardiac magnetic resonance. Results The mean change in LVEF between baseline and follow-up for all patients was 4 ± 6% (p = 0.006). Change in LVEF and LVESV over time did not differ significantly among the 4 groups. Patients actively treated with any stem cell approach showed similar changes in LVEF and LVESV versus control subjects, with a small but significant reduction in infarct area (p = 0.038). Conclusions In our study, 3 different bone marrow–derived stem cell approaches in AMI did not result in improvement of LVEF or volumes compared with standard AMI care (Trial of Hematopoietic Stem Cells in Acute Myocardial Infarction [TECAM]; NCT00984178 )