Details

Autor(en) / Beteiligte

• Wu, Chenglin
• Ying, Anguo
• Ren, Shibin

Titel

Fabrication of polymeric micelles with core–shell–corona structure for applications in controlled drug release

Ist Teil von

• Colloid and polymer science, 2013-04, Vol.291 (4), p.827-834

Ort / Verlag

Berlin/Heidelberg: Springer-Verlag

Erscheinungsjahr

2013

Quelle

SpringerLink Journals - AutoHoldings

Beschreibungen/Notizen

• Thermo-responsive polymeric micelles of poly (ethylene glycol)- b -poly(2-hydroxyethyl methacrylate- g -lactide)- b -poly( N -isopropylacrylamide) (PEG-P(HEMA-PLA)-PNIPAM) with core–shell–corona structure were fabricated for applications in controlled drug release. The graft copolymer of PEG-P(HEMA-PLA)-PNIPAM was self-assembled into core–shell micelles with a densely PLA core and mixed PEG/PNIPAM shells at 25 °C in aqueous media. By increasing the temperature above the lower critical solution temperature of PNIPAM, these core–shell micelles could be converted into core–shell–corona micelles because of the collapse of PNIPAM block on the PLA core as the inner shell and the soluble PEG block stretching outside as the outer corona. Anticancer drug doxorubicin (DOX) was loaded in the polymeric micelles as a model drug. Compared with polymeric micelles formed by liner PEG- b -PLA- b -PNIPAM triblock copolymer, these polymeric micelles exhibited higher loading capacity, and release of DOX from the polymeric micelles with core–shell–corona structure was well-controlled.