Details

Autor(en) / Beteiligte

• Saida, Ken
• Kawasaki, Kenji
• Hirabayashi, Kanae
• Akazawa, Yohei
• Kubota, Seiko
• Kasuga, Eriko
• Kusakari, Mai
• Ishida, Takefumi
• Kitamura, Masatomo
• Baba, Atsushi
• Koike, Kenichi

Titel

Exfoliative toxin A staphylococcal scalded skin syndrome in preterm infants

Ist Teil von

• European journal of pediatrics, 2015-04, Vol.174 (4), p.551-555

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2015

Quelle

Springer LINK 全文期刊数据库

Beschreibungen/Notizen

• Staphylococcal scalded skin syndrome (SSSS) demonstrates dermal symptoms due to exfoliative toxin (ET) A or ETB produced by Staphylococcus aureus . We examined the association between anti-ETA antibodies and SSSS onset in neonates. Three preterm infants carried an ETA-producing strain of S. aureus , manifesting as either SSSS or bullous impetigo; a full-term infant carrying the same strain was asymptomatic. The infants (n=106) were categorized into three groups according to their gestational age (GA) as follows: <30 weeks, 30–37 weeks, and >37 weeks. The measured levels of anti-ETA antibody in the three infants displaying SSSS were low before the onset of dermal symptoms; only the asymptomatic full-term infant displayed a high antibody level. Anti-ETA antibody levels in the preterm group with a GA of <30 weeks were statistically lower than those in the term infant group; the prevalences of anti-ETA antibodies above a cutoff value in the three groups of neonates were 55 % (18/33) among preterm infants with a GA <30 weeks, 73 % (25/34) among those with a GA of 30–37 weeks, and 90 % (35/39) among infants with a GA >37 weeks. Conclusion : The presence of anti-ETA antibodies below a particular cutoff level might be associated with SSSS onset in preterm infants.