Details

Autor(en) / Beteiligte

• Peng, Jiao
• Tsang, Julia Yuen Shan
• Li, Daxu
• Niu, Na
• HO, Derek Hoi Hang
• Lau, Kwok Fai
• Lui, Vincent Chi Hang
• Lamb, Jonathan Robert
• Chen, Yan
• Tam, Paul Kwong Hang

Titel

Inhibition of TGF-[beta] signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages

Ist Teil von

• Cancer letters, 2013-05, Vol.331 (2), p.239

Ort / Verlag

Clare: Elsevier Limited

Erscheinungsjahr

2013

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Highlights * TLR7 expressed on TAMs but not the tumor cells. * Ligation of TLR7+ TGF-β receptor I inhibitor in TAM/tumor cell co-culture system re-programmed TAMs to M1 macrophage. * In vivo TLR7 ligation/TGF-β receptor I inhibition increased tumor apoptosis and elevated lymphocytes infiltration.