Details

Autor(en) / Beteiligte

• Rothenberg, Marc E., MD, PhD
• Bousquet, Jean, MD

Titel

News Beyond Our Pages

Ist Teil von

• Journal of allergy and clinical immunology, 2012-09, Vol.130 (3), p.561-562

Ort / Verlag

St. Louis: Elsevier Limited

Erscheinungsjahr

2012

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The results also indicate the dependency of MDSCs on mast cells to exert their immunoregulatory effects. [...]we should reconsider targeting MDSC elimination in neoplastic patients and perhaps redirect our efforts to modulate their interaction with mast cells. The authors propose that the identified epitopes from their systematic survey of peptides from common allergens can be used in the future to characterize the changes in T-cell responses in patients that occur with the seasons, with immunotherapy, and with disease severity.We asked senior author Alessandro Sette, from the La Jolla Institute for Allergy and Immunology, to tell us about the implications of these results: "These results demonstrate that the approach to T cell epitope identification based on prediction of broad HLA binding capacity can be successfully applied to large collection of allergens.