Details

Autor(en) / Beteiligte

• Nakajo, Masatoyo
• Nakajo, Masayuki
• Kajiya, Yoriko
• Goto, Yuko
• Jinguji, Megumi
• Tanaka, Sadao
• Fukukura, Yoshihiko
• Tani, Atsushi
• Higashi, Michiyo

Titel

Correlations of ^sup 18^F-fluorothymidine uptake with pathological tumour size, Ki-67 and thymidine kinase 1 expressions in primary and metastatic lymph node colorectal cancer foci

Ist Teil von

• European radiology, 2014-12, Vol.24 (12), p.3199

Ort / Verlag

Heidelberg: Springer Nature B.V

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• To examine correlations of ^sup 18^F-fluorothymidine (FLT) uptake with pathological tumour size and immunohistochemical Ki-67, and thymidine kinase 1 (TK-1) expressions in primary and metastatic node colorectal cancer foci. Thirty primary cancers (PCs) and 37 metastatic nodes (MNs) were included. FLT uptake was assessed by visual scores (non-visible: 0-1 and visible: 2-4), standardized uptake value (SUV), and correlated with size, Ki-67, and TK-1. SUV was measured in visible lesions. FLT heterogeneity was assessed by visual scores (no heterogeneous uptake: 0 and heterogeneous uptake: 1-4). Forty-two lesions were visible. The visible group showed significantly higher values than the non-visible group in size, Ki-67, and TK-1 (each p<0.05). Size correlated significantly with visual score (PC; ρ=0.74 and MN; ρ=0.63), SUVmax (PC; ρ=0.49, and MN; ρ=0.76), and SUVmean (PC; ρ=0.40 and MN; ρ=0.76) (each p<0.05). Visual score correlated significantly with size (ρ=0.86), Ki-67max (ρ=0.35), Ki-67mean (ρ=0.38), TK-1max (ρ=0.35) and TK-1mean (ρ=0.25) (each p<0.05). No significant correlations were found between FLT uptake and Ki-67 or TK-1 in 42 visible lesions (each p>0.05). Heterogeneous FLT uptake was noted in 73 % (22/30) of PCs. FLT uptake correlated with size. Heterogeneous FLT distribution in colorectal cancers may be one of the causes of weak or lack of FLT uptake/Ki-67 or TK-1 correlation. * FLT uptake correlated well with tumour size in colorectal cancer * Weak or lack of FLT uptake/Ki-67 and TK-1 correlations were observed * Immunohistochemical Ki-67 and TK-1 expressions are not always correlated with FLT uptake [PUBLICATION ABSTRACT]