Details

Autor(en) / Beteiligte

• Choi, Jun-Hyeok
• Park, Pojeong
• Baek, Gi-Chul
• Sim, Su-Eon
• Kang, SukJae Joshua
• Lee, Yeseul
• Ahn, Seo-Hee
• Lim, Chae-Seok
• Lee, Yong-Seok
• Collingridge, Graham L
• Kaang, Bong-Kiun

Titel

Effects of PI3K[beta] overexpression in the hippocampus on synaptic plasticity and spatial learning

Ist Teil von

• Molecular brain, 2014-11, Vol.7

Ort / Verlag

London: BioMed Central Ltd

Erscheinungsjahr

2014

Quelle

SpringerLink

Beschreibungen/Notizen

• Previous studies have shown that a family of phosphoinositide 3-kinases (PI3Ks) plays pivotal roles in the brain; in particular, we previously reported that knockout of the [beta] isoform of PI3K (PI3K[beta]) in mice impaired synaptic plasticity and reduced behavioral flexibility. To further examine the role of PI3K[beta] in synaptic plasticity and hippocampus-dependent behavioral tasks we overexpressed p110[beta], the catalytic subunit of PI3K[beta], in the hippocampal CA1 region. We found that the overexpression of p110[beta] impairs NMDA receptor-dependent long-term depression (LTD) and hippocampus-dependent spatial learning in the Morris water maze (MWM) task. In contrast, long-term potentiation (LTP) and contextual fear memory were not affected by p110[beta] overexpression. These results, together with the previous knockout study, suggest that a critical level of PI3K[beta] in the hippocampus is required for successful induction of LTD and normal learning.