Details

Autor(en) / Beteiligte

• Win, Yip-Foo
• Choong, Chen-Shang
• Dang, Jia-Chin
• Iqbal, Muhammad Adnan
• Quah, Ching Kheng
• Majid, Amin Malik Shaw Abdul
• Teoh, Siang-Guan

Titel

Polymeric seven-coordinated organotin(IV) complexes derived from 5-amino-2-chlorobenzoic acid and in vitro anti-cancer studies

Ist Teil von

• Journal of coordination chemistry, 2014-10, Vol.67 (20), p.3401-3413

Ort / Verlag

Abingdon: Taylor & Francis

Erscheinungsjahr

2014

Quelle

Taylor & Francis

Beschreibungen/Notizen

• Cancer cases are alarmingly increasing worldwide, and newer chemotherapeutic agents are needed. Recent analogs of cisplatin (carboplatin, lobaplatin, nedaplatin and oxaliplatin) and their marketing as advanced chemotherapeutic drugs have furthered the interest in metal-based anti-cancer drugs. In the current study, two new polymeric organotin(IV) carboxylate complexes (1 and 2) have been synthesized and characterized. Spectroscopic studies showed that coordination took place via carboxylates. Furthermore, X-ray crystallographic study on 1 indicated that it possesses a monomeric structure and exists in polymeric formation due to additional Sn-N coordination, assigning seven coordinations to each metal ion. Both the complexes were tested against three cancerous (human colon cancer, HCT 116; breast cancer, MCF-7; and leukemia, K562) and one non-cancerous (3T3-L1) cell lines. Complex 1 showed exceptional cytotoxicity against cancerous cell lines (IC 50  = 1.0 μM for HCT 116; 258.7 nM for MCF-7; and 46.7 nM K562) and remained comparatively non-toxic against normal cells (IC 50  = 37.0 μM). This shows that both complexes have selective cytotoxicity against cancer cells.