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A genome-wide linkage scan of bipolar disorder in Latino families identifies susceptibility loci at 8q24 and 14q32
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2014-09, Vol.165B (6), p.479-491
Gonzalez, Suzanne
Camarillo, Cynthia
Rodriguez, Marco
Ramirez, Mercedes
Zavala, Juan
Armas, Regina
Contreras, Salvador A.
Contreras, Javier
Dassori, Albana
Almasy, Laura
Flores, Deborah
Jerez, Alvaro
Raventós, Henriette
Ontiveros, Alfonso
Nicolini, Humberto
Escamilla, Michael
2014
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Gonzalez, Suzanne
Camarillo, Cynthia
Rodriguez, Marco
Ramirez, Mercedes
Zavala, Juan
Armas, Regina
Contreras, Salvador A.
Contreras, Javier
Dassori, Albana
Almasy, Laura
Flores, Deborah
Jerez, Alvaro
Raventós, Henriette
Ontiveros, Alfonso
Nicolini, Humberto
Escamilla, Michael
Titel
A genome-wide linkage scan of bipolar disorder in Latino families identifies susceptibility loci at 8q24 and 14q32
Ist Teil von
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2014-09, Vol.165B (6), p.479-491
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Quelle
Wiley Online Library Core Title
Beschreibungen/Notizen
A genome‐wide nonparametric linkage screen was performed to localize Bipolar Disorder (BP) susceptibility loci in a sample of 3757 individuals of Latino ancestry. The sample included 963 individuals with BP phenotype (704 relative pairs) from 686 families recruited from the US, Mexico, Costa Rica, and Guatemala. Non‐parametric analyses were performed over a 5 cM grid with an average genetic coverage of 0.67 cM. Multipoint analyses were conducted across the genome using non‐parametric Kong & Cox LOD scores along with Sall statistics for all relative pairs. Suggestive and significant genome‐wide thresholds were calculated based on 1000 simulations. Single‐marker association tests in the presence of linkage were performed assuming a multiplicative model with a population prevalence of 2%. We identified two genome‐wide significant susceptibly loci for BP at 8q24 and 14q32, and a third suggestive locus at 2q13‐q14. Within these three linkage regions, the top associated single marker (rs1847694, P = 2.40 × 10−5) is located 195 Kb upstream of DPP10 in Chromosome 2. DPP10 is prominently expressed in brain neuronal populations, where it has been shown to bind and regulate Kv4‐mediated A‐type potassium channels. Taken together, these results provide additional evidence that 8q24, 14q32, and 2q13‐q14 are susceptibly loci for BP and these regions may be involved in the pathogenesis of BP in the Latino population. © 2014 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1552-4841
eISSN: 1552-485X
DOI: 10.1002/ajmg.b.32251
Titel-ID: cdi_proquest_journals_1553150199
Format
–
Schlagworte
bipolar disorder
,
Bipolar Disorder - genetics
,
Central-American
,
Chromosomes, Human, Pair 14 - genetics
,
Chromosomes, Human, Pair 8 - genetics
,
Family
,
family studies
,
Genetic Linkage
,
Genetic Loci - genetics
,
Genetic Predisposition to Disease
,
Genetics
,
Genome-Wide Association Study
,
Hispanic Americans - genetics
,
Humans
,
Mexican
,
Mexican-American
,
Models, Genetic
,
Phenotype
,
Sequence Analysis, DNA
,
Statistics, Nonparametric
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