Details

Autor(en) / Beteiligte

• Rothenberg, Marc E., MD, PhD
• Bousquet, Jean, MD

Titel

News Beyond Our Pages

Ist Teil von

• Journal of allergy and clinical immunology, 2011-02, Vol.127 (2), p.297-298

Ort / Verlag

St. Louis: Elsevier Limited

Erscheinungsjahr

2011

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Terrier et al noted increased expression of IL-17RB, TRAF6, and JunB in biopsy specimens from patients with CSS, which is consistent with TH2 dominance.We asked senior author David Saadoun, MD, PhD, Université Pierre et Marie Curie, Paris, to comment on the importance of this study: "Increase in blood and tissue eosinophilia is commonly considered as the consequence of the production of TH2 cytokines by CD4+ T cells, in particular IL-5, which is the most potent stimulator of eosinophil production and functional activation of mature eosinophils. . Stary et al further evaluated the Langerhans cells from the OCS control group and discovered that they expressed an immature phenotype, increased TGF-β expression, and increased receptor activator for nuclear factor κB. The authors noted that these conditions would support regulatory T-cell expansion.