Details

Autor(en) / Beteiligte

• He, Jing
• Tsai, Louis M
• Leong, Yew Ann
• Hu, Xin
• Ma, Cindy S
• Chevalier, Nina
• Sun, Xiaolin
• van denberg, Kirsten
• Rockman, Steve
• Ding, Yan
• Zhu, Lei
• Wei, Wei
• Wang, Changqi
• Karnowski, Alexander
• Belz, Gabrielle T
• Ghali, Joanna R
• Cook, Matthew C
• Riminton, D Sean
• Veillette, André
• Schwartzberg, Pamela L
• Mackay, Fabienne
• Brink, Robert
• Tangye, Stuart G
• Vinuesa, Carola G
• Mackay, Charles R
• Li, Zhanguo
• Yu, Di

Titel

Circulating Precursor CCR7loPD-1hiCXCR5+CD4+T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

Ist Teil von

• Immunity (Cambridge, Mass.), 2013-10, Vol.39 (4), p.770

Ort / Verlag

Cambridge: Elsevier Limited

Erscheinungsjahr

2013

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Follicular B helper T (Tfh) cells support high affinity and long-term antibody responses. Here we found that within circulating CXCR5+CD4+T cells in humans and mice, the CCR7loPD-1hisubset has a partial Tfh effector phenotype, whereas CCR7hiPD-1locells have a resting phenotype. The circulating CCR7loPD-1hisubset was indicative of active Tfh differentiation in lymphoid organs and correlated with clinical indices in autoimmune diseases. Thus the CCR7loPD-1hisubset provides a biomarker to monitor protective antibody responses during infection or vaccination and pathogenic antibody responses in autoimmune diseases. Differentiation of both CCR7hiPD-1loand CCR7loPD-1hisubsets required ICOS and BCL6, but not SAP, suggesting that circulating CXCR5+helper T cells are primarily generated before germinal centers. Upon antigen reencounter, CCR7loPD-1hiCXCR5+precursors rapidly differentiate into mature Tfh cells to promote antibody responses. Therefore, circulating CCR7loPD-1hiCXCR5+CD4+T cells are generated during active Tfh differentiation and represent a new mechanism of immunological early memory.