Cancer letters, 2011-08, Vol.307 (2), p.182
2011
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- Autor(en) / Beteiligte
- Titel
- MicroRNA-519d targetsMKi67and suppresses cell growth in the hepatocellular carcinoma cell line QGY-7703
- Ist Teil von
- Cancer letters, 2011-08, Vol.307 (2), p.182
- Ort / Verlag
- Clare: Elsevier Limited
- Erscheinungsjahr
- 2011
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- MicroRNAs (miRNAs) are small non-coding RNAs that regulate the translation of target mRNA transcripts. In this study, we demonstrated that miR-519d was downregulated in human HCC and could suppress growth of the human HCC cell line QGY-7703. Bioinformatics analysis indicated thatMKi67was a putative target of miR-519d. In an EGFP reporter system, we confirmed thatMKi67was a direct target gene of miR-519d. Furthermore, knockdown ofMKi67inhibited QGY-7703 cell growth. These findings indicate that miR-519d targets theMKi67transcript and suppresses HCC cell growth, suggesting that miR-519d has a tumor suppressive role in human HCC pathogenesis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2011.04.002Titel-ID: cdi_proquest_journals_1547347013
- Format
- –
- Schlagworte
- Apoptosis, Cell growth, Cloning, Gene expression, Liver cancer, Mortality, Pathogenesis, Proteins, Rodents, Studies, Tumorigenesis, Tumors